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The active region of TB-500 (the LKKTETQ sequence) binds G-actin monomers, preventing their polymerization into filamentous F-actin

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The transition from the lipid environment of the BBB endothelial cell membrane to the aqueous interstitial fluid of the brains extracellular space necessitates further consideration of a drug and its delivery vehicles physicochemical properties, including size, surface charge, shape, and molecular weight (Sykova and Nicholson, 2008

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doi:10.1076/opep.10.4.215.15906

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